Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
نویسندگان
چکیده
منابع مشابه
Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.
Influenza hemagglutinin (HA) is the primary target of the humoral response during infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly neutralizing antibodies (bnAbs), thereby limiting their efficacy. Although several bnAbs bind to the conserved stem domain of HA, focusing the immune response to this conserved stem in the presence of the immunodominant, varia...
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ژورنال
عنوان ژورنال: npj Vaccines
سال: 2017
ISSN: 2059-0105
DOI: 10.1038/s41541-017-0036-2